Na/Ca-exchanger overexpression in rat Na/Ca Exchanger Overexpression Impairs Frequency- and Ouabain-Dependent Cell Shortening in Adult Rat Cardiomyocytes
نویسندگان
چکیده
Address for correspondence: Prof. Dr. med. Robert H.G. Schwinger, M.D., Laboratory of Muscle Research and Molecular Cardiology, Department of Internal Medicine III, University of Cologne, Joseph-Stelzmann-Str. 9, 50924 Cologne, Germany, telephone: 0049-221-478-3138, fax: 0049-221-478-3746, Email: [email protected] Articles in PresS. Am J Physiol Heart Circ Physiol (May 27, 2004). 10.1152/ajpheart.00397.2003
منابع مشابه
Na+/Ca2+ exchanger overexpression impairs frequency- and ouabain-dependent cell shortening in adult rat cardiomyocytes.
The Na(+)/Ca(2+) exchanger (NCX) may influence cardiac function depending on its predominant mode of action, forward mode or reverse mode, during the contraction-relaxation cycle. The intracellular Na(+) concentration ([Na(+)](i)) and the duration of the action potential as well as the level of NCX protein expression regulate the mode of action of NCX. [Na(+)](i) and NCX expression have been re...
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